This How-To guide is part of a series from Patient Focused Medicines Development (PFMD) that provides a set of instructions on how to involve patients in the co-creation of plain language summaries (PLS) of peer-reviewed publications, including journal articles and conference presentations. These guides have been co-created in a multi-stakeholder environment built with the Patient Engagement Quality Guidance as a starting point. All How-To’s are connected and provide a full set of instructions on how to involve patients across the research, development, and delivery of medicines.